Esmé Kamphuis (born May 22, 1983, Zwolle) is a former Dutch heptathlete, who has competed as a bobsledder since 2004. Her best Bobsleigh World Cup finish was 12th in the two-woman event at Königssee in February 2008.
Kamphuis also finished tenth in the two-woman event at the 2008 FIBT World Championships in Altenberg. She competed with Tine Veenstra at the 2010 Winter Olympics, where they finished eighth in the two-woman event.